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目的观察斯普林注射液配合放、化疗治疗中晚期肺癌的疗效。方法将147例中晚期肺癌患者随机分为斯普林注射液配合放、化疗组(治疗组,75例),单纯放、化疗组(对照组,72例),两组放、化疗方法相同,治疗组在放、化疗开始即给予斯普林10mL,加入0.9%氯化钠注射液250mL中静滴,连用14d,21d为1周期,共4～6周期,对多个临床指标进行比较观察。结果治疗组近期疗效为60.0%,对照组为48.6%,两组无统计学差异(P>0.05)。治疗组1、2年生存率分别为58.9%、41.1%,对照组分别为42.3%、25.4%,两组有统计学差异(P<0.05)。治疗组患者的生活质量、治疗后T细胞亚群及NK细胞活性明显高于对照组,血液学各项指标下降程度、消化道不良反应及放射性食管炎均明显轻于对照组,两组有统计学差异(P<0.05)。结论斯普林注射液用于配合放、化疗治疗中晚期肺癌有一定疗效。
Objective To observe the curative effect of Spring injection combined with radiotherapy and chemotherapy on advanced lung cancer. Methods A total of 147 patients with advanced lung cancer were randomly divided into Splenectomy plus chemotherapy group (75 cases) and chemotherapy alone group (72 cases). The radiotherapy and chemotherapy were the same in both groups, In the treatment group, 10 mL of Spring was given at the beginning of chemotherapy, and 250 mL of 0.9% sodium chloride injection was added intravenously for 14 days and 21 days for one cycle for a total of 4 to 6 cycles. Clinical data were compared and observed. Results The curative effect in the treatment group was 60.0% and that in the control group was 48.6%. There was no significant difference between the two groups (P> 0.05). The 1-year and 2-year survival rates were 58.9% and 41.1% in the treatment group and 42.3% and 25.4% in the control group, respectively. There was significant difference between the two groups (P <0.05). The quality of life, T lymphocyte subpopulation and NK cell activity in the treatment group were significantly higher than those in the control group. The degree of hematology decline, gastrointestinal adverse reactions and radiation esophagitis were significantly lower than those in the control group Learning difference (P <0.05). Conclusion Spring Injection for radiotherapy and chemotherapy in the treatment of advanced lung cancer have a certain effect.