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研究牛黄解毒片经口对大鼠的急性和14天毒性。方法：按卫生部药政局《中药新药研究指南（药学，药理学，毒理学）》的规定进行。结果：牛黄解毒片用6．43g／kg给大鼠一次灌胃，无死亡。持续14天给药，6．43g／kg和3.21g／kg剂量组大鼠体重增长缓慢，病理检查发现肝损伤。结论：牛黄解毒片经口对大鼠的急性LD_(50)大于6．43g／kg（临床用量50倍）；经口给药14天，毒作用阈值为3．21g／kg（临床用量25倍），靶器官为肝。
To study the acute and 14-day toxicity of Niuhuang Jiedu tablets by mouth to rats. Method: According to the regulations of the “Guide to New Drug Research of Traditional Chinese Medicines (Pharmacy, Pharmacology, Toxicology)” of the Ministry of Health of the Ministry of Health. RESULTS: Niuhuang Jiedu Tablets were given once per gavage at 6.43g/kg without death. After 14 days of administration, the weight gain of rats in the 6.43 g/kg and 3.21 g/kg dose groups was slow. Liver damage was found by pathological examination. Conclusion: The acute LD_(50) of Niuhuang Jiedu Tablets is greater than 6.43g/kg (50 times of clinical dosage) by oral administration to rats, and the oral dose is 3.21g/kg (25 times of clinical dosage) by oral administration for 14 days. ), The target organ is the liver.