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早在三十多年前,取自我国特有植物的喜树碱类物质(camptothecins)就表现出良好的抗瘤活性,在生物碱中令人瞩目。80年代,拓扑异构酶被确认为该类药物作用的独特靶点,再次引起了学者们对该类药物的关注。随着对喜树碱类药物的不断深入研究,证明羟基喜树碱(HCPT)是所有天然喜树碱同类物或合成喜树碱中活性最大的天然衍生物,其对肠癌、卵巢癌、肺癌等恶性肿瘤显示了令人鼓舞的治疗效果,成为抗癌药物中的一支生力军。作为常用的细胞凋亡剂,羟基喜树碱被广泛用于恶性肿瘤细胞凋亡的研究。本文就该研究作一综述,以了解目前进展,指导临床工作。1 羟基喜树碱的化学结构及作用机制羟基喜树碱是喜树碱经结构改造后的半成品,化学结构
As early as more than thirty years ago, camptothecins derived from endemic plants in our country showed good anti-tumor activity, which attracted much attention in alkaloids. In the 80s, topoisomerase was identified as a unique target of the class of drugs, again attracted the scholars of these drugs attention. With the continuous research on camptothecins, hydroxycamptothecin (HCPT) is proved to be the most active natural derivative of all natural camptothecins or synthetic camptothecins, and has high activity on colorectal cancer, ovarian cancer, Malignant tumors such as lung cancer have shown encouraging therapeutic effects and become a new force in anti-cancer drugs. As a commonly used apoptosis agent, hydroxycamptothecin is widely used in the study of apoptosis of malignant tumor cells. This article reviews the research to understand current progress and guide clinical work. 1 hydroxy camptothecin chemical structure and mechanism of action camptothecin hydroxy camptothecin after structural transformation of semi-finished products, chemical structure