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目的:探讨Ⅲ(pNn 2)期表皮生长因子受体(EGFR)基因野生型肺腺癌完全切除并辅助化疗患者术后放疗(PORT)的价值及预后影响因素。n 方法:回顾性分析2009—2016年间郑州大学附属肿瘤医院完全切除的Ⅲ(pNn 2)期EGFR基因野生型肺腺癌患者172例，均接受>4个周期含铂两药联合方案辅助化疗，根据术后是否胸部放疗分为PORT组和non-PORT组。采用n Kaplan-n Meier法生存分析并n log-n rank法检验，n Cox模型多因素预后分析。n 结果:全组中位总生存期，3、5年总生存率分别为40个月，55.9%、28.3%；中位无瘤生存期，3、5年无瘤生存率分别为17个月，24.5%、13.0%。PORT组比non-PORT组中位无瘤生存期提高(29个月∶13个月，n P＝0.001)，总生存期有延长的趋势(51个月∶38个月，n P＝0.151)。亚组分析发现多站Nn 2、Nn 2转移数目≥3个、跳跃性Nn 2患者接受PORT的无瘤生存获益明显(n P0.05)。n 结论:完全切除的Ⅲ(pNn 2)期EGFR基因野生型接受标准辅助化疗肺腺癌患者PORT可能改善无瘤生存并有延长总生存趋势，仍需扩大样本进一步研究。n “,”Objective:To evaluate the value and identify the prognosic factors of postoperative radiotherapy (PORT) in completely resected stage Ⅲ(pNn 2) lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) wild-type who received adjuvant chemotherapy.n Methods:Clinical data of 172 patients with stage Ⅲ(pNn 2) EGFR wild-type lung adenocarcinoma who underwent radical resection and adjuvant chemotherapy from 2009 to 2016 were retrospectively analyzed. All patients received platinum-based adjuvant chemotherapy combining two drugs for>4 cycles, and divided into the PORT group and the non-PORT group. The survival rate was calculated byn Kaplan-n Meier method and log-rank test, and multivariate prognostic analysis was performed by n Cox’s regression model.n Results:Among 172 patients, the median overall survival (OS), 3-year and 5-year OS rates were 40 months, 55.9% and 28.3%, respectively. The median disease-free survival (DFS), 3-year and 5-year DFS rates were 17 months, 24.5% and 13.0%, respectively. DFS was significantly improved in the PORT group (29 months n vs. 13 months, n P=0.001), whereas OS did not significantly differ between two groups (51 months n vs. 38 months, n P=0.151). In subgroup analysis, DFS of patients with multistation Nn 2 or the number of Nn 2 metastases of≥3 or skip Nn 2 in the PORT group was significantly longer (n P0.05).n Conclusions:For patients with completely resected stage Ⅲ(Nn 2) EGFR wild-type lung adenocarcinoma receiving adjuvant chemotherapy, PORT might increase DFS and have a trend toward longer OS. However, these findings remain to be validated by large sample size investigations.n