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角膜上皮细胞、晶状体上皮细胞、视网膜色素上皮细胞等眼内细胞的细胞膜上存在不同的离子通道和泵,导致细胞内外选择性的离子分布,从而产生一个内源性电场和电流.许多眼科疾病,如慢性角膜溃疡、白内障术后的后囊膜混浊及视网膜变性可能与内源性电场的破坏和异常有关.电场如何通过影响组织、细胞的功能参与疾病发生和发展及可能的疾病防治策略均是该领域的研究热点和新思路.本文就细胞内源性电场产生的机制、细胞在直流电场中的生物学变化、电场作用的相关机制及电场在临床上应用的前景进行综述,希望为今后眼科疾病的治疗提供更广阔的思路.“,”Corneal epithelial cells,lens epithelial cells,and retinal pigment epithelium cells contain a vast array of ion channels and pumps.The selective permeability to different ions generates endogenous electric fields and currents in those tissues.Abnormalities in the endogenous electric fields may underlie many ocular diseases,for example chronic corneal ulcers,posterior capsule opacity after cataract surgery,and retinopathies.How the electric fields influence the tissues and cells and participate in the occurrence of the ocular diseases is a hotspot of research in this field.This article briefly reviewed the mechanism of how the endogenous electrical activities are generated,the responses of ocular cells to applied electric fields,potential intracellular signaling mechanisms and clinical implications.Further understanding of this aspect is likely to offer new insights into ocular diseases.