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目的:探讨临床肝纤维化的诊断手段。方法:用放射免疫测定法(RIA)检测经肝活检病理确诊的正常人及其它各型慢肝患者共81例血清Ⅲ型前胶原肽(PⅢP)含量,并用维多利亚蓝染色对全部肝活检的肝组织切片进行胶原纤维染色并分级。结果:肝活检纤维化程度与血清 PⅢP含量呈显著正相关(r=0.982,P<0.005)。慢性活动性肝炎(CAH)和肝硬变(LC)患者血清 PⅢP显著高于正常人和慢性迁延性肝炎(CPH)患者(P<0.001)。结论:血清 PⅢP可作为动态观察肝纤维化程度的良好指标,并有助于临床上对慢性肝病进程及预后的判断。
Objective: To investigate the clinical diagnosis of liver fibrosis. Methods: A total of 81 serum samples of type Ⅲ procollagen peptide (P Ⅲ P) were detected by radioimmunoassay (RIA) in 81 normal subjects and other chronic liver cancer patients. The liver biopsy specimens Tissue sections were stained with collagen fibers and graded. Results: The degree of fibrosis in liver biopsy was positively correlated with serum PⅢP content (r = 0.982, P <0.005). Serum PⅢP levels in patients with chronic active hepatitis (CAH) and cirrhosis (LC) were significantly higher than those in patients with normal and chronic persistent hepatitis (CPH) (P <0.001). Conclusion: Serum P Ⅲ P can be used as a good indicator to observe the degree of liver fibrosis dynamically, and contribute to the clinical judgment of the course and prognosis of chronic liver disease.