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长链非编码RNA(Long non-coding RNA,LncRNA)在人类生命活动过程中发挥着重要的作用,并维持着正常的细胞功能,然而它们的异常表达与肿瘤发生密切相关。近年来,越来越多的研究表明,LncRNA通过类似癌基因或抑癌基因的作用,参与前列腺癌细胞的增殖、侵袭、转移等调控过程,并由于特定LncRNA在肿瘤当中表达的高特异性,可作为前列腺癌诊断及预后的指标。本文对近年来LncRNA与前列腺癌发生、发展的关系及诊治的研究进展作一综述。
Long-chain non-coding RNA (LncRNA) plays an important role in human life activities and maintains normal cell functions. However, their abnormal expression is closely related to tumorigenesis. In recent years, more and more researches show that LncRNA participates in the regulation of prostate cancer cell proliferation, invasion and metastasis through the function of similar oncogenes or tumor suppressor genes. Due to the high specificity of LncRNA expression in tumors, Can be used as an indicator of prostate cancer diagnosis and prognosis. This article reviews the recent progress in the relationship between LncRNA and prostate cancer and the development of diagnosis and treatment.