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为探讨锌与单疱角膜炎(HSK)发病的关系,应用原子吸收光谱法对家兔实验性HSK和HSK病人的血清和泪液锌含量变化进行了动态测定和分析。结果表明,兔血清锌含量在造模后初期一过性升高(P<0.05);泪液锌含量在发病期间一直下降(P<0.05),并与角膜病变程度呈负相关(r=-0.72,p<0.05)。病人血清锌含量在发病期、痊愈后半年和正常对照组之间差异无显著意义(P>0.05);泪液锌含量在发病期低于愈后半年和正常对照组(P<0.05),后二者之间差异无显著意义(P>0.05)。泪液锌含量下降与HSK发病相关。
In order to explore the relationship between the zinc and the pathogenesis of herpes simplexis (HSK), the change of zinc content in serum and tear of rabbits with experimental HSK and HSK was measured by atomic absorption spectrometry. The results showed that the content of zinc in rabbit serum increased transiently (P <0.05), while the content of zinc in tear fluid decreased gradually (P <0.05), and was negatively correlated with the degree of corneal disease (r = -0.72 , p <0.05). There was no significant difference in serum zinc level between the control group and the control group (P> 0.05). The content of zinc in lacrimal fluid was lower than that in the normal control group (P <0.05) There was no significant difference between the two groups (P> 0.05). Zinc tear decreased the incidence of HSK.