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目的探讨维甲酸(retinoic acid)对宫颈上皮内瘤样病变(cervical Intraepithelial Neoplasia,CIN)细胞增殖与分化的影响。方法选择CIN患者140例,研究组予维A酸口服,10mg/次,3次/d,连用2月;3月后两组病例再行阴道镜检查及宫颈活检或宫颈锥形切除,活检标本进行病理检查及细胞增殖及凋亡指数测定。结果治疗组病变消退或病变级别降低与对照组比较有统计学意义,细胞凋亡指数升高、Ki-67降低,P<0.05,与对照组比较有统计学意义。结论维甲酸对CIN患者异常细胞有诱导分化作用,值得临床进一步研究应用。
Objective To investigate the effect of retinoic acid on the proliferation and differentiation of cervical intraepithelial neoplasia (CIN) cells. Methods A total of 140 patients with CIN were enrolled in this study. The study group was orally administered with Vitamin A acid at 10 mg / time for 3 times daily for 2 months. After 3 months, colposcopy and cervical biopsy or cervical conization were performed in both groups. Biopsy specimens Pathological examination and cell proliferation and apoptosis index determination. Results In the treatment group, the lesions subsided or the lesions were reduced compared with the control group. The apoptosis index was increased, Ki-67 was decreased, P <0.05, compared with the control group was statistically significant. Conclusion Retinoic acid induces differentiation of abnormal cells in patients with CIN, which deserves further clinical application.