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“依赖导管”生存的紫绀型先天性心脏病婴儿,出生后需常规应用前列腺素E(PGE、PGE_2)。但已有报道长期低剂量应用PGE可产生一些副作用。杵状指(趾)是心肺疾病中常见的临床体征之一,但产生的机制尚不明确。有一种学说认为:舒血管物质在体循环中蓄积,从而导致指(趾)间动静脉吻合枝开放,结果引起杵状指(趾)。因为已知PGE_2在肺脏分解同时又有抑制交感神经的缩血管作用。故PGE与杵状指(趾)形成可能有密切的关系。本文报告一例早产儿。900g,诊断右心发育不全、三尖瓣和肺动脉瓣狭窄、室间隔缺损、肺动脉发育不良。为维持其血氧饱和度(70～75％),手术前采用PGE静点治疗共107天,治疗40天时指(
“Dependent on catheter” survival of cyanotic congenital heart disease infants, the need for routine use of prostaglandin E (PGE, PGE_2). However, long-term, low-dose use of PGE has been reported to produce some side effects. Clubbing (toes) is one of the common clinical signs of cardiopulmonary disease, but the mechanism is not yet clear. There is a doctrine that: vasodilator accumulation in the systemic circulation, leading to arteriovenous anastomosis between the fingers open, resulting in clubbing (toe). Because PGE 2 is known to decompose in the lungs while inhibiting sympathetic vasoconstriction. Therefore, PGE and clubbing (toe) may form a close relationship. This article reports a case of premature children. 900g, diagnosis of right hypoplastic, tricuspid and pulmonary valve stenosis, ventricular septal defect, pulmonary dysplasia. In order to maintain its oxygen saturation (70 ~ 75%), preoperative PGE static point treatment for a total of 107 days, 40 days of treatment refers to (