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本文观察了CD3 McAb 对PHA 和TPA 诱导的20～36周龄人胚胸腺细胞增殖反应的调节作用。结果表明:CD3McAb 不能单独诱导人胚胸腺细胞增殖反应,但却能显著地促进TPA 诱导的人胚胸腺细胞增殖和抑制PHA 诱导的人胚胸腺细胞增殖,并呈剂量依赖关系;加入外源性rHulL—2能促进人胚胸腺细胞对CD3McAb 诱导的应答反应,而rHuIL—1则无此作用。此结果对于了解人胚胸腺表达CD_3抗原细胞的功能水平及CD_3分子的生物学作用有一定的意义.
This paper investigates the regulatory effect of CD3 McAb on the proliferative responses of human embryonic thymocytes from 20 to 36 weeks induced by PHA and TPA. The results showed that CD3McAb could not induce the proliferation of human embryo thymocytes alone, but significantly promoted the proliferation of human embryonic thymocytes induced by TPA and inhibited the proliferation of PHA-induced human embryo thymocytes in a dose-dependent manner. The addition of exogenous rHulL -2 can promote the response of human embryonic thymocytes to CD3McAb-induced response, while rHuIL-1 does not. This result is of certain significance for understanding the functional level of CD3 antigen cells in human embryo and the biological function of CD3 molecule.