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26例急性穿壁性心肌梗塞(下称心梗)患者,在胸痛发作12小时内(平均6小时)进行随机对照或硝苯吡啶治疗。其中13例硝苯吡啶10mg舌下含服,随后每6小时含服10mg,共24小时,13例随机对照。所有患者都插入Swan-Gans导管测定心率、收缩压和舒张压、心排出量和肺动脉楔压,并连续进行心电图记录和监控。在研究前后常规测定生化和血液学数值。应用硝苯吡啶后30分钟动脉血压从127/78mmHg降至
Twenty-six patients with acute transmural myocardial infarction (MI) were randomized or treated with nifedipine within 12 hours of onset of chest pain (mean, 6 hours). Thirteen nifedipine sublingual 10mg, followed by every 6 hours with 10mg, a total of 24 hours, 13 cases of randomized controlled. Heart rate, systolic and diastolic blood pressure, cardiac output and pulmonary wedge pressure were measured in all patients with Swan-Gans catheterization and electrocardiographic recording and monitoring were performed continuously. Biochemical and hematologic values were routinely determined before and after the study. Arterial blood pressure was reduced from 127/78 mmHg 30 minutes after nifedipine was applied