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目的:探讨血浆中的氨基末端脑钠肽原(NT-proBNP)及肿瘤坏死因子α(TNF-α)水平与冠状动脉粥样硬化性心脏病(冠心病)的相关性。方法:入选冠心病患者120例,根据冠心病类型分为稳定型心绞痛组、不稳定型心绞痛组及急性心肌梗死组,35例冠状动脉造影正常的受试者作为对照组,比较不同病变组及对照组之间的NT-proBNP及TNF-α水平的差异;同时按照冠状动脉血管病变的数目,将冠心病患者分为单支病变组、双支病变组、三支病变组,比较病变支数与NT-proBNP和TNF-α的相关性。结果:本研究表明NT-proBNP及TNF-α在对照组、稳定型心绞痛组、不稳定型心绞痛组及急性心肌梗死组间存在明显差异,此外TNF-α水平与冠状动脉血管病变支数存在显著性相关;但是NT-proBNP血浆水平与病变支数无显著性相关。结论:NT-proBNP及TNF-α可以作为反映冠状动脉病变程度的重要指标。
Objective: To investigate the relationship between the levels of plasma NT-proBNP and tumor necrosis factor-α (TNF-α) and coronary atherosclerotic heart disease (CHD). Methods: A total of 120 patients with coronary heart disease were enrolled. According to the types of coronary heart disease, they were divided into stable angina pectoris group, unstable angina pectoris group and acute myocardial infarction group, and 35 subjects with normal coronary angiography as control group. The levels of NT-proBNP and TNF-α in the control group were compared. According to the number of coronary artery disease, the coronary heart disease patients were divided into single vessel disease group, double vessel disease group and triple vessel disease group, Correlation with NT-proBNP and TNF-α. Results: This study showed that NT-proBNP and TNF-α in the control group, stable angina pectoris group, unstable angina pectoris group and acute myocardial infarction group there is a significant difference, in addition TNF-α levels and coronary artery lesions were significant However, there was no significant correlation between NT-proBNP plasma levels and the number of lesions. Conclusion: NT-proBNP and TNF-α can be used as an important index to reflect the degree of coronary artery disease.