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Prostate cancer non-coding RNA 1 (PRNCR1),a lncRNA transcribed from 8q24,is involved in carcinogenesis and development of varies cancer.Several molecular epidemiology studies revealed that the association between PRNCR1 single-nucleotide polymorphisms (SNPs) and cancer risk,but the results remain controversial.In order to derive a more precise evaluation,we conducted a meta-analysis to summarize all eligible case-control studies to evaluate the association between SNPs in PRNCR1 and the overall cancer susceptibility.A systematic literature search on PubMed and Web of science database was up to January 1st,2017.Finally,a total of six articles involving 2804 cases and 3233 controls samples were included in this meta-analysis.Homozygous,heterozygous,dominant,recessive and allelic models were used to analyze the associations between SNPs in PRNCR1 and cancer risk in the Asian population by using the odds ratio (OR) and 95％ confidence interval (95％CIs).Heterogeneity and publication bias were used to measure the robustness of our findings.Significant associations between the PRNCR1 rs16901946 polymorphism and cancer risk were observed (GG vs.AA+AG:OR =1.19,95％ CI =1.07-1.32,P =0.002,I2=0.0％) in Asian population.Moreover,subgroup analyses by cancer type indicated that rs1016343 C ＞ T and rs16901946 A ＞G was associated with an increase prostate cancer risk.In addition,no significant association was detected between rs13252298 A ＞ G and rs7007694 C ＞ T polymorphism and cancer susceptibility.In conclusion,our meta-analysis suggests that PRNCR1 polymorphisms may be associated with cancer susceptibility in Asian populations,particularly in prostate cancer.