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目的通过对我市产前诊断机构4年来的数据分析,了解宁德地区孕中期唐氏征筛查、诊断现状,为改进和完善产前筛查诊断管理工作提供依据。方法根据2011年1月1日-2014年12月31日孕中期产前筛查诊断的病例收集、妊娠结局的随访进行统计分析,结果全市4年来中孕期产前血清学筛查总量76 425例、分娩数211 792例、唐氏征筛查覆盖率为36.08%,筛查高风险2710例,其中:21-三体高风险2369例、18-三体高风险96例、NTD高风险245例;21-三体高风险811例及18-三体高风险30例、共841例行羊水诊断,诊断率34.12%。结论宁德地区的产前筛查诊断率较低、需进一步宣传普及。
Objective To understand the status of Down’s syndrome screening and diagnosis during the second trimester in Ningde through the data analysis of our prenatal diagnosis institution in the past four years and provide the basis for improving and perfecting prenatal screening diagnosis and management. Methods According to the statistical analysis of the cases of prenatal screening diagnosis during the second trimester of pregnancy from January 1, 2011 to December 31, 2014 and the follow-up of pregnancy outcome, the total amount of prenatal serological screening in the first trimester of pregnancy in the past four years was 76,425 Cases, 211 792 cases of childbirth, Tang’s levy screening coverage was 36.08%, 2710 cases of high risk screening, including: 2169 trisomy 2369 cases, 96 cases of high trisomy 18, NTD 245 cases of high risk; 21-trisomy 811 cases and 18-trisomy 30 cases, a total of 841 cases of amniotic fluid diagnosis, the diagnosis rate was 34.12%. Conclusions The prenatal screening diagnosis rate in Ningde area is relatively low, which needs further publicity and popularization.