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在手性相转移催化剂存在下,于室温固-液两相体系,将甘氨酸乙酯二苯酮希夫碱进行相转移催化碳-单烷基化,合成了12个光学活性的α-氨基酸乙酯二苯酮希夫碱的烷基衍生物,并进一步水解得到相应的光学活性α-氨基酸乙酯盐酸盐.光学纯度为3.2%～96.6%.
In the presence of a chiral phase transfer catalyst, 12 optically active α-amino acids B were synthesized by phase-transfer carbonylation of glycine ethyl benzophenone Schiff base in the solid-liquid two-phase system at room temperature Ester benzophenone Schiff base alkyl derivatives, and further hydrolysis to give the corresponding optically active α-amino acid ethyl ester hydrochloride Optical purity of 3.2% ~ 96.6%.