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氯霉素治疗伤寒近二十年效果逐渐降低,复发率高,对骨髓有不同程度抑制之可能,甚至引起再生障碍性贫血;因此临床医生在使用氯霉素时总是有担心其副作用过大的心理。近几年国内陆续报道应用复方新诺明治疗伤寒取得较好的疗效且副作用少。我们应用复方新诺明、氯霉素分组治疗伤寒并作疗效对比,两组病例各7例,均为1979年住院确诊患者,均有高热,血培养有伤寒杆菌生长或肥达氏反应阳性(“0”1:160,“H”1:160以上),周围血白细胞5,000～9,000个/立方毫米,无夹杂症。给药方法与疗效:氯霉素每日1克,分4次口服(静脉给药同量),当体温正常后减量再用7～14天;复方新诺明每日4～6片,分两次服,体温正
Chloramphenicol treatment of typhoid effect gradually reduced in the past 20 years, the high recurrence rate, the degree of bone marrow suppression may be, and even cause aplastic anemia; Therefore, clinicians always have to worry about when using chloramphenicol side effects Psychology. In recent years, one after another reported that the domestic compound cotrimoxazole treatment of typhoid fever to achieve better efficacy and fewer side effects. We use the combination of cotrimoxazole, chloramphenicol group for the treatment of typhoid fever and efficacy comparison, two cases of seven cases, all diagnosed in 1979 were patients with fever, blood culture with Salmonella typhi growth or Widal reaction ( “0” 1: 160, “H” 1: 160 or more), peripheral blood leukocytes 5,000-9,000 / mm3, no inclusions. Dosage and efficacy: chloramphenicol 1 g daily, divided into 4 oral (intravenous administration of the same amount), when normal body temperature and then reduce the amount of reuse 7 to 14 days; cotrimoxazole daily 4 to 6, In two clothes, body temperature is positive