激光多普勒技术测定组织血流及其在高温治癌研究中的意义

• 作 者: 毛慧生 宁连胜 孙慧 赵文华 安秀梅
• 机 构: 天津市肿瘤研究所,天津市肿瘤研究所,天津市肿瘤研究所,天津市肿瘤研究所,天津市肿瘤研究所,
• 出 处: 中国肿瘤临床
• 发表日期: 1992年03期
• 关键词: 小鼠 激光多普勒 增敏作用 肿瘤移植 激光探头 血管舒张 乏氧 实验观察 小鼠肿瘤 鼠足

应用激光多普勒血流仪测量比较津白Ⅱ号小鼠三个部位皮肤的血流,观察HDZ对血流的影响,评价了HDZ的体内热增敏作用。结果发现,同一小鼠不同部位的血流是不同的,同一部位的连续6天结果无何区别。但同部位小鼠间的血流差别可达1倍以上。提示了预测放、化、热疗的疗效时,监测个体血流的前后变化有重要意义。2.5mg/kg以上的HDZ可以明显降低血流75％左右。HDZ与高温联合应用时对肿瘤显示了热增敏效应。

The blood flow of the skin of three parts of Jinbai II mice was measured by laser Doppler flowmetry. The effect of HDZ on blood flow was observed and the thermal sensitization of HDZ was evaluated. As a result, it was found that the blood flow of different parts of the same mouse was different, and there was no difference in results of the same site for 6 consecutive days. However, the difference in blood flow between mice in the same site can be more than doubled. It is important to monitor the changes in the blood flow before and after predicting the efficacy of radiotherapy, chemotherapy, and hyperthermia. 2.5mg/kg or more of HDZ can significantly reduce blood flow by about 75%. In combination with high temperature, HDZ shows a thermal sensitizing effect on tumors.