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目的评价结核分枝杆菌特异性T细胞检测(T-SPOT.TB)在结核性胸膜炎诊断中的应用价值。方法对96例明确诊断为结核性胸膜炎患者的血液标本进行结核分枝杆菌特异性T细胞检测,同时对所有病例采用ELISA法血清抗结核抗体试验(TB-AB)检测及结核菌素纯蛋白衍生物(PPD)试验。结果三种方法检测阳性率分别为88.5%、52.1%和64.6%,T.SPOT.TB与TB-AB及PPD试验阳性检出率差异有统计学意义(P<0.05)。结论 T.SPOT.TB与TB-AB检测及PPD试验相比,在结核性胸膜炎诊断中有较高的敏感性,可作为结核性胸膜炎的重要辅助诊断方法,具有一定的临床推广价值。
Objective To evaluate the diagnostic value of Mycobacterium tuberculosis specific T cell test (T-SPOT.TB) in the diagnosis of tuberculous pleurisy. Methods Mycobacterium tuberculosis specific T cells were detected in 96 cases of patients with definite diagnosis of tuberculous pleurisy. ELISA was used to detect TB antibody (TB-AB) in all cases and tuberculin-pure protein Material (PPD) test. Results The positive rates of the three methods were 88.5%, 52.1% and 64.6%, respectively. The positive detection rates of T.SPOT.TB, TB-AB and PPD were significantly different (P <0.05). Conclusion Compared with TB-AB test and PPD test, T.SPOT.TB has a higher sensitivity in the diagnosis of tuberculous pleurisy, which can be used as an important auxiliary diagnostic method for tuberculous pleurisy and has certain clinical value.