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目的统计分析绵阳地区献血人群2008年1月-2010年12月HBV的流行率、新发率,评估HBV在该地区的流行情况。方法收集2008年1月-2010年12月100 429人次献血者人口统计学资料、2轮第3代ELISA试剂初筛和确证数据。分别计算初次献血者和重复献血者的HBV流行率,利用文献报道的新发率评估模型,评估重复献血人群的新发率。结果 2008年1月-2010年12月绵阳地区初次献血和重复献血人群的HBV流行率依次为0.97%和0.04%,重复献血人群中的HBV感染新发率为0.32%。结论绵阳地区献血人群具有较高的流行率和新发率,可能引起较高的HBV输血残余风险,应考虑采用第4代ELISA初筛试剂和核酸检测(NAT)降低该地区的HBV对血液安全的影响。
Objective To statistically analyze the prevalence and new incidence of HBV in blood donors in Mianyang from January 2008 to December 2010 and evaluate the prevalence of HBV in this area. Methods The data of 100 429 donors from January 2008 to December 2010 were collected, and the data of two rounds of the third generation ELISA reagent screening and confirmatory data were collected. The prevalence of HBV in primary blood donors and repeat donors were calculated respectively. The new incidence rate reported in the literature was used to evaluate the new incidence of repeated blood donation. Results From January 2008 to December 2010, the prevalences of HBV in the first donation and repeated donation groups in Mianyang were 0.97% and 0.04%, respectively, and the new incidence of HBV infection among repeat donors was 0.32%. Conclusion The blood donation population in Mianyang area has a high prevalence and new incidence, which may cause higher residual risk of HBV transfusion. We should consider the use of 4th generation ELISA screening reagents and nucleic acid detection (NAT) to reduce the HBV blood safety in this area Impact.