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本实验以大鼠穿梭箱主动回避反应（ＡＡＲ）的习得和消退为学习记忆的指标，研究了海马内生长抑素（ＳＳ）和γ－氨基丁酸（ＧＡＢＡ）在学习记忆中的作用。结果如下：（１）经训练而建立了ＡＡＲ的大鼠，其海马内ＳＳ较对照组显著增高，而海马内ＧＡＢＡ含量却明显降低；（２）海马内注入ＳＳ的耗竭剂半胱胺（Ｃｙｓ，２０ｇ／Ｌ）使大鼠ＡＡＲ的习得受到明显损害，ＡＡＲ的消退显著加速，海马内ＳＳ明显降低，而ＧＡＢＡ含量却显著升高；（３）海马内注入ＧＡＢＡ（２００ｇ／Ｌ）使大鼠ＡＡＲ的消退显著加速的同时，其海马内ＳＳ含量亦显著降低。由此表明，海马内ＳＳ可能有促进学习记忆的作用，而海马内ＧＡＢＡ升高则有相反的效应；二者在海马调控学习记忆过程中具有重要作用。
In this study, the acquisition and extinction of active avoidance response (AAR) in rat shuttle were used as learning and memory indicators to study the role of somatostatin (SS) and gamma-aminobutyric acid (GABA) in learning and memory in the hippocampus. The results were as follows: (1) The AAR rats were trained to significantly increase SS in the hippocampus and decrease the content of GABA in the hippocampus. (2) Cys , 20g / L) significantly impaired the learning ability of AAR in rats. The AAR regress was significantly accelerated, and the content of SS in the hippocampus was significantly decreased while the content of GABA was significantly increased. (3) GABA (200g / L) AAR mice significantly accelerated the regression, the SS content in the hippocampus also significantly reduced. Thus, SS in the hippocampus may promote the learning and memory, but the up-regulation of GABA in the hippocampus has the opposite effect. Both of them play an important role in the regulation of learning and memory in the hippocampus.