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继 DDS 作为一种有效的治疗麻风药后,又发现了氯苯酚嗪和利福平这两种一线药。1960年 Shepard 鼠足垫模型建立不久,1964年 Pettit 等氏就用此模型证实了耐 DDS 麻风菌,以后相继发现了耐氯苯酚嗪和耐利福平麻风菌。1984年 Guelpa—Lauras 等氏又发现对氯苯酚嗪和利福平双重耐药的麻风菌。此外,麻风治疗中还存在持久菌(Persister)的问题。Waters 等氏发现经长期充分的抗麻风药单疗或联疗后,均还会存在“持久菌”。
Following the DDS as an effective treatment for leprosy drugs, two first-line drugs, chlorophenazine and rifampicin, were also found. Shortly after the establishment of the Shepard rat footpad model in 1960, Pettit et al. Used this model to confirm the resistance to DDS leprosy bacilli in 1964. Afterwards, chlorpromazine and rifampin-resistant leprosy were successively found. In 1984, Guelpa-Lauras et al. Found leprosy, a dual drug resistant to chlorophenazine and rifampicin. In addition, the treatment of leprosy still exists persister bacteria (Persister) problems. Waters et al. Found that “long-lasting bacteria” were present even after prolonged periods of adequate anti-leprosy or combination therapy.