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目的评估吉西他滨和顺铂联合化疗方案在Ⅳ期膀胱癌中的治疗效果。方法 对未进行过任何抗肿瘤治疗的Ⅳ期膀胱癌患者49例,给予吉西他滨1000mg/m2,第1、8、15天静脉滴注;顺铂70mg/m2,第2天静脉滴注;每4周重复,共4个周期。化疗前后常规检查血常规、肝肾功能、膀胱CT及彩超,观察疗效及不良反应发生情况。结果完全缓解10例,部分缓解21例,病情平稳11例,进展7例,治疗总有效率63.3%。部分缓解患者肿瘤变小,继行经尿道膀胱肿瘤电切术。不良反应主要为骨髓抑制,白细胞减少40例、血小板减少12例;发热2例,消化道反应20例。未出现严重脏器毒性反应及过敏反应。结论吉西他滨联合顺铂治疗晚期膀胱癌安全、有效。
Objective To evaluate the therapeutic effect of gemcitabine and cisplatin combination chemotherapy in stage IV bladder cancer. Methods Forty-nine patients with stage IV bladder cancer who did not undergo any anti-tumor therapy were given gemcitabine 1000mg / m2, intravenous drip on days 1, 8 and 15; cisplatin 70mg / m2 on day 2; Weeks repeat, a total of 4 cycles. Before and after chemotherapy routine examination of blood, liver and kidney function, CT and color Doppler ultrasound to observe the efficacy and adverse reactions. The results of complete remission in 10 cases, partial remission in 21 cases, stable condition in 11 cases, progress in 7 cases, the total effective rate of 63.3%. Some patients with remission to reduce the tumor, followed by transurethral resection of the bladder tumor. Adverse reactions mainly bone marrow suppression, 40 cases of leukopenia, thrombocytopenia in 12 cases; fever in 2 cases, gastrointestinal reactions in 20 cases. No serious organ toxicity and allergic reactions. Conclusion Gemcitabine combined with cisplatin in the treatment of advanced bladder cancer is safe and effective.