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Clentiazem是地尔硫(艹卓)的类似物,半减期较长,作用强度约为后者的3倍。早期的动物试验显示,本品是通过扩张小动脉而降低动脉压的。本文评价本品对原发性高血压(EHT)病人的血流动力学和代谢效应。研究对象为停用一切药物至少2周后舒张压为11.9～15.3 kPa的EHT病人。所有病人在静推安慰剂后,依次静推本品0.025、0.025和0.05mg/kg,每剂间隔至少5分
Clentiazem is an analogue of diltiazem with a longer half-life of about three times the intensity of action. Early animal tests show that this product is through the expansion of arterioles and arterial pressure. This article evaluates the hemodynamic and metabolic effects of this product in patients with essential hypertension (EHT). Subjects were EHT patients with diastolic blood pressure of 11.9 to 15.3 kPa after discontinuing all medications for at least 2 weeks. All patients in the static push placebo, followed by static push the goods 0.025,0.025 and 0.05mg / kg, each dose interval of at least 5 points