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氨基糖甙类是一种治疗G~-细菌严重感染的基本抗生素,通常的给药方式是每日2～3次。近来这种方式的合理性和效果受到质疑。氨基糖甙类抗生素的杀菌括性有赖于其浓度。每日1次大剂量应用能取得最大的杀菌效果。其后作用(Post-antibiotic effect)能防止细菌在抗生素低浓度时再生长。氨基糖甙类抗生素在肾皮质的摄取率是有饱和性的,单次给药较多次给药的累积小。对于肾脏、耳和前庭的毒性,动物实验和健康志愿者的试验显示单次给药均较多次给药为轻。本文用临床前瞻性、随机分组和双盲观察
Aminoglycosides are a basic antibiotic used to treat severe G- bacterial infections, usually 2 to 3 times daily. The reasonableness and effectiveness of this approach have been questioned recently. Sterilization of aminoglycoside antibiotics depends on its concentration. Once a day high-dose application can achieve the greatest bactericidal effect. The Post-antibiotic effect prevents the bacteria from growing again at low concentrations of antibiotics. Aminoglycoside antibiotics in the renal cortex uptake rate is saturated, a single administration more cumulative administration small. Toxicity to the kidneys, ears, and vestibules has been shown in both animal and healthy volunteers to be administered more frequently than in single doses. This paper uses a prospective, randomized, double-blind observation