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本文对在国家金属汞浓度卫生标准下作业的48名日光灯管厂工人,同时测定了血尿γ-GT、β_2-MG、Cr及尿Hg,并以上海59名园艺工人为对照组比较研究。结果:接汞组尿γ-GT30.64±9.66U/gCr,对照组23.91±6.49U/g Cr(P<0.05);接汞组尿β_2-MG345.32±613.83μg/g Cr,对照组96.93±67.91μg/gCr(P<0.01),二者均有显著差异;接汞组尿γ-GT、β_2-MG异常率为22.93％和20.83％,与对照组亦有显著差异(P<0.01,0.05)。尿γ-GT异常者11例与尿汞、工龄及尿β_2-MG等均无显著相关。提示尿γ-GT、β_2-MG为肾损伤的敏感指标,若与尿汞监测联合使用,可提高其临床早期诊断价值。
In this paper, 48 fluorescent tube factory workers working under the national standard of metal mercury concentration were tested for hematuria γ-GT, β_2-MG, Cr and urinary Hg at the same time, and 59 Shanghai horticultural workers were compared as a control group. Results: Urine γ-GT was 30.64 ± 9.66U / gCr in control group and 23.91 ± 6.49U / g Cr in control group (P <0.05). Urinary β2-MG345.32 ± 613.83μg / 96.93 ± 67.91μg / gCr (P <0.01). The abnormal rates of γ-GT and β_2-MG in the indirect mercury group were 22.93% and 20.83%, which were also significantly different from those in the control group (P <0.01) , 0.05). Eleven patients with abnormal urine γ-GT had no significant correlation with urine mercury, length of service, and β_2-MG in urine. Prompted urinary γ-GT, β_2-MG as a sensitive indicator of kidney damage, if used in combination with urinary mercury monitoring, can improve its early clinical diagnostic value.