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目的:探讨阴茎多发性血管球瘤(GT)的临床病理特征、诊断及鉴别诊断。方法:对1例罕见的阴茎多发性GT的13岁患儿进行临床、组织形态学及免疫组织化学染色观察,并结合文献进行探讨。结果:阴茎多发性GT临床表现为多发的血管团状小结节,有触痛,无红肿,无表面分泌物。镜下肿瘤由丰富的血管和围绕血管生长的多层上皮样瘤细胞组成。血管多为扩张的静脉,似海绵状血管瘤。瘤细胞大小一致,呈圆形或立方形,胞浆淡红色或稍透明,核稍大,圆形或卵圆形,位于细胞中央,核染色质细致均匀,未见明显异型性和核分裂。间质局灶水肿及粘液变性。免疫表型:肿瘤细胞表达SMA、Vimentin。结论:发生于阴茎的多发性GT极其罕见,多发生于儿童,结合患儿临床症状、组织病理学特点和免疫组化标记一般可明确诊断,多发性GT易累及全身和复发,需进行全面查体和术后随访。
Objective: To investigate the clinical and pathological features, diagnosis and differential diagnosis of penile multiple glioma (GT). Methods: A 13-year-old infantile penis with multiple penis was selected for clinical, histomorphologic and immunohistochemical staining and the literature was explored. Results: Penile multiple GT clinical manifestations of multiple vascular small nodules, tenderness, no swelling, no surface secretions. Microscopic tumors consist of abundant blood vessels and multilamellar epithelioid tumor cells that grow around the blood vessels. Vascular mostly dilated veins, like cavernous hemangioma. Tumor cells of the same size, was round or cubic, cytoplasm pale red or slightly transparent, slightly larger nucleus, round or oval, located in the center of the cell, nuclear chromatin fine uniform, no obvious atypia and mitotic. Interstitial focal edema and mucus degeneration. Immunophenotype: Tumor cells express SMA, Vimentin. CONCLUSIONS: Multiple GTs occurring in the penis are extremely rare and occur mostly in children. Combined with the clinical symptoms, histopathological features and immunohistochemical markers in children, definite diagnosis can be made. Multiple GT can easily affect the whole body and recurrence, Body and postoperative follow-up.