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胰高血糖素样肽1是体内一种重要的肠促胰素,能够通过多种途径降低血糖,在调节葡萄糖稳态中起重要作用,可用于预防和治疗糖尿病。胰高血糖素样肽1的受体分布广泛,除了胰腺组织外,还分布于脑、肺脏、心脏、肾脏等。近年来对胰高血糖素样肽1的研究发现其对心血管系统具有保护作用,如调节心率、血压,改善血管内皮功能、舒张血管、改善心肌缺血、改善心功能等。对这些作用的研究将为临床治疗糖尿病和心血管疾病提供新的方法。
Glucagon-like peptide 1 is an important incretin in the body that can lower blood glucose through a variety of pathways and plays an important role in the regulation of glucose homeostasis and can be used to prevent and treat diabetes. Glucagon-like peptide 1 receptors are widely distributed, in addition to the pancreas, but also distributed in the brain, lung, heart, kidney and so on. In recent years, studies on glucagon-like peptide 1 have found that it has a protective effect on the cardiovascular system, such as regulating heart rate, blood pressure, improving endothelial function, relaxing blood vessels, improving myocardial ischemia, and improving cardiac function. Research on these roles will provide a new approach to the clinical treatment of diabetes and cardiovascular diseases.