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肥大心肌细胞的动作电位延长 ,短暂外向钾电流 (Ｉｔｏ)减少。因为Ｉｔｏ以Ｋｖ 4.3为主 ,作者观察新生大鼠心肌细胞对心肌细胞肥大的已知刺激因子 :ＡｎｇⅡ和苯肾上腺素(ＰＥ)的应答。ＲＮａｓｅ保护测定和ｉｍｍｕｎｏｂｌｏｔｓ反映ＡｎｇⅡ和ＰＥ均下调Ｋｖ 4.3ｍＲＮＡ和
The action potential of hypertrophic cardiomyocytes is prolonged, and transient outward potassium current (Ito) is decreased. Since Ito is predominantly Kv 4.3, the authors observed the response of neonatal rat cardiomyocytes to known stimulators of cardiomyocyte hypertrophy: Ang II and phenylephrine (PE). RNase protection assays and immunoblots reflect that both AngⅡ and PE downregulate Kv 4.3 mRNA and