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血清中有100余种蛋白成分,其中前白蛋白、白蛋白、α_1抗胰蛋白酶蛋白、α_2热稳定性糖蛋白、运铁蛋白等,系由或主要由肝细胞制造,肝损害时制造减少,血清中浓度降低。临床上常用血清白蛋白浓度来反映肝损害程度,但白蛋白体内半衰期长达19～27天,肝合成白蛋白的能力降低50%时,血中自蛋白浓度仅降低20%,因此,血清白蛋白测定不是急性肝损害的敏感指标。近几年来人们企图通过测定血清中“快运转蛋白”(rapid-turnover protein)来反映肝损害的发生及其程度。这些蛋白体内半衰期短,当损害发生后较短期内血清中浓度即可有变化。前白蛋白即属于快运转蛋白之一。本文报告我们对50例
Serum has more than 100 kinds of protein components, including prealbumin, albumin, α_1 antitrypsin protein, α 2 thermostable glycoprotein, transferrin, etc., made by or mainly made of liver cells, reduced manufacturing loss of liver damage, Serum concentration decreased. Clinical serum albumin concentration to reflect the degree of liver damage, but albumin in vivo half-life of up to 19 to 27 days, liver synthesis of albumin 50% lower ability to reduce blood from the protein concentration only 20%, therefore, serum Protein determination is not a sensitive indicator of acute liver injury. In recent years, people have attempted to reflect the occurrence and extent of liver damage by measuring the “rapid-turnover protein” in serum. The short half-life of these proteins in vivo can change when serum concentrations in the shorter period of time after injury occur. Prealbumin is one of the fast acting proteins. This article reports on our 50 cases