论文部分内容阅读
Objective:The aim of our study was to explore the short-term ef icacy of platinum-based combined with concur-rent chemoradiotherapy for local y advanced non-smal-celllung cancer (NSCLC). Methods:Between 2006 to 2010, 78 cases of local y advanced NSCLC were enrol ed into this trial. Al patients were given platinum-based chemotherapy combined with concurrent three-dimensional conformal radiotherapy (3-DCRT). Chest CT scans were obtained during end-expiratory and end-inspiratory pauses when performing positioning. Image fusion was done after the image data was transferred to treat-ment plan system (TPS). The target volume was delineated on the fusion images. The chemotherapy was given on the first day of radiotherapy. Comprehensive examinations were conducted 4-6 weeks after concurrent chemoradiotherapy to assess short-term ef icacy. Results:Complete remission (CR) was achieved in 8 cases and partial remission (PR) in 54 cases. The ef iciency rate reached 79.5%. Grade III-IV radiation esophagitis occurred in 11.5%. No exit and death cases during treat-ment. Conclusion:Concurrent chemo-radiotherapy could significantly improve the short-term ef icacy and prolong survival of stage III NSCLC, meanwhile the adverse reactions could be tolerated.