Vasculogenic mimicry in non-small cell lung cancer and its relationship with tumor stage

• 作 者: Xiangqian Lu Xiao Li Fangzhen
• 机 构: Department of 0ncology
• 出 处: 中德临床肿瘤学杂志（英文版）
• 发表日期: 2004年期
• 关键词: vasculogenic mimicry (VM) angiogenesis non-smal cell lung cancer (NSCLC) targete

Objective:The purpose of the study was to study the mechanism of vasculogenic mimicry (VM) and its relation-ship with tumor stage in non-smal celllung cancer (NSCLC). Methods:Forty-two patients with NSCLC were col ected, 19 belonged to the early stage (stages I+II) while 23 were late stage (stages III+IV). Moreover, 20 patients got surgical treat-ment and 22 got chemotherapy. We studied the relationship of VM with stage, chemotherapeutic ef ect, HIF-1α, microves-sel density (MVD) and clinicopathologic features. Results:VM in patients of early stages were significantly more than late stages (68.4%vs 26.1%, P=0.006), and the positive rate of VM was proportional to HIF-1α(P=0.034). But no correlation was found between VM and chemotherapeutic ef ect (14.3%vs 26.7%, P=1.00) or MVD (P>0.05). Furthermore, we found VM also showed a negative correlation with distant metastases and lymph nodes metastases (P