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[目的]探讨癌巢内肿瘤浸润淋巴细胞(TIL)对直肠癌术前放疗近期局部疗效的影响。[方法]直肠癌单纯术前放疗病人107例,术前放疗30Gy/10f/12d,2周后手术。分析TIL与放疗疗效的关系。[结果]随访107例直肠癌术前单纯放疗病人21(2～86)个月,放疗后病理完全缓解14例(13.1%)。单因素分析发现放疗后TIL、放疗后病理降级、放疗后纤维化与局部疗效相关(P<0.01)。Logistic多元回归分析发现放疗后淋巴细胞浸润是局部控制的显著因素。[结论]直肠癌放疗后癌巢内有肿瘤浸润淋巴细胞对局部控制有利。
[Objective] To investigate the effect of tumor infiltrating lymphocytes (TIL) on the recent local curative effect of preoperative radiotherapy in rectal cancer. [Method] 107 cases of rectal cancer were treated with preoperative radiotherapy only, 30Gy / 10f / 12d before operation and 2 weeks after surgery. Analysis of the relationship between TIL and radiotherapy efficacy. [Results] A total of 107 patients with rectal cancer who underwent radiotherapy alone were treated 21 (2-86) months prior to radiotherapy. Pathology was completely relieved in 14 patients (13.1%) after radiotherapy. Univariate analysis found that TIL after radiotherapy, pathological degradation after radiotherapy, fibrosis after radiotherapy and local efficacy (P <0.01). Logistic multiple regression analysis found that lymphocyte infiltration after radiotherapy was a significant factor of local control. [Conclusion] Tumor infiltrating lymphocytes in cancer nests after rectal cancer radiotherapy are good for local control.