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目的:探索米非司酮联合甲基睾丸素治疗子宫内膜非典型增生的新途径。方法:对无禁忌证、拒绝手术自愿接受米非司酮与甲基睾丸素治疗的子宫内膜非典型增生患者120例进行分析。结果:用药前后子宫内膜厚度分别为(5.8±0.96)mm及(1.43±0.38)mm,用药后子宫内膜腺上皮呈增生早期改变。结论:米非司酮配伍小剂量甲基睾丸素能有效抑制子宫内膜非典型增生,治疗效果满意。
Objective: To explore a new way of mifepristone combined with methyltestosterone in the treatment of atypical hyperplasia of the endometrium. Methods: 120 patients with endometrial atypical hyperplasia without contraindication and refused to accept surgery for mifepristone and methyltestosterone were randomly divided into two groups. Results: The thickness of endometrium before and after treatment were (5.8 ± 0.96) mm and (1.43 ± 0.38) mm, respectively. The endometrial glandular epithelium showed early changes after treatment. Conclusion: Mifepristone combined with low-dose methyltestosterone can effectively inhibit the atypical hyperplasia of the endometrium, and the treatment effect is satisfactory.