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目的探讨结核药联合利福喷丁治疗肺结核过程中对患者免疫功能、炎症因子、VEGF及MMP-9变化的影响。方法选取肺结核患者80例,随机分为研究组和对照组,对照组给予异烟肼、吡嗪酰胺、对氨基水杨酸及利福喷丁治疗,观察组在对照组基础上加用结核丸治疗,对比分析两组患者治疗前和治疗6个月后免疫功能、炎症因子、VEGF及MMP-9水平变化。结果治疗前,两组患者CD_3~+、CD_4~+、CD4/CD8、IL-4、TNF-α、VEGF和MMP-9比较差异均无统计学意义;治疗后,研究组结果和对照组比较,差异具有统计学意义。结论结核药与利福喷丁联合用药可以有效控制病情,明显改善患者免疫功能、降低VEGF及MMP-9水平、降低炎症反应。
Objective To investigate the effects of tuberculosis combined with rifapentine on immune function, inflammatory factors, VEGF and MMP-9 in patients with pulmonary tuberculosis. Methods Eighty patients with pulmonary tuberculosis were selected and randomly divided into study group and control group. The control group was given isoniazid, pyrazinamide, p-aminosalicylic acid and rifapentine. The observation group was given tuberculosis pills on the basis of the control group The levels of immune function, inflammatory factors, VEGF and MMP-9 in two groups before and 6 months after treatment were compared and analyzed. Results Before treatment, there were no significant differences in the levels of CD_3 ~ +, CD_4 ~ +, CD4 / CD8, IL-4, TNF-α, VEGF and MMP-9 between the two groups , The difference was statistically significant. Conclusion The combination of tuberculosis and rifapentine can effectively control the disease, significantly improve the immune function, reduce the levels of VEGF and MMP-9 and reduce the inflammatory reaction.