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基于二氧化硅荧光纳米颗粒(FSiNP)的荧光信号同步指示功能,通过实时、原位活体荧光成像技术,并结合离体器官成像、组织切片成像以及尿液荧光成像等方法,系统地研究了不同尺寸二氧化硅荧光纳米颗粒在裸鼠活体内的分布与代谢.活体成像结果表明纳米颗粒尺寸越小,血液循环时间越长,全身分布情况越明显,随着时间的延长纳米颗粒逐渐聚集到肝脏、膀胱等部位;通过离体器官成像和组织切片成像进一步证实了活体成像所观察到的结果.同时,肾脏组织切片以及尿液成像结果显示,颗粒越小越容易通过泌尿系统排出体外.研究结果为今后开展不同尺寸纳米颗粒材料在活体内的应用研究打下基础.
Based on the fluorescence signal synchronization indication function of silica fluorescent nanoparticles (FSiNP), the effects of different fluorescent signals were studied systematically through real-time in situ fluorescence imaging and in vitro organ imaging, tissue section imaging and urine fluorescence imaging The distribution and metabolism of size silica nanoparticles in nude mice in vivo The results of in vivo imaging showed that the smaller the size of the nanoparticles and the longer the blood circulation, the more obvious the distribution of the whole body, and the aggregation of nanoparticles gradually to the liver , Bladder and other parts of the body by further organ imaging and tissue section imaging further confirmed the results observed in vivo imaging.At the same time, kidney tissue sections and urine imaging results showed that the smaller the particle size, the more easily through the urinary system excretion results This will lay the foundation for the future research on the application of different size nanoparticle materials in vivo.