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目的探讨玉屏风颗粒联合孟鲁司特钠治疗小儿反复性呼吸道感染后咳嗽的临床疗效。方法选取柳城县妇幼保健院儿科2013—2015年收治的反复性呼吸道感染后咳嗽患儿200例,随机分为A、B、C、D组,各50例。A组患儿给予相关抗生素治疗,B组患儿在A组基础上给予孟鲁司特钠治疗,C组患儿在A组基础上给予玉屏风颗粒治疗,D组患儿给予玉屏风颗粒联合孟鲁司特钠治疗,4组患儿均持续治疗3个月。比较4组患儿的临床疗效及治疗前后CD_8~+细胞分数、CD_4~+细胞分数、CD_4~+/CD_8~+细胞比值、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)。结果D组患儿临床疗效优于A、B、C组(P<0.05),A、B、C组患儿临床疗效比较,差异无统计学意义(P>0.05)。治疗前,4组患儿CD_8~+细胞分数、CD_4~+细胞分数、CD_4~+/CD_8~+细胞比值及IgG、IgA比较,差异无统计学意义(P>0.05);治疗后,D组患儿CD_8~+细胞分数低于A、B、C组,CD_4~+细胞分数、CD_4~+/CD_8~+细胞比值及IgG、IgA高于A、B、C组(P<0.05)。结论采用玉屏风颗粒联合孟鲁司特钠治疗小儿反复性呼吸道感染后咳嗽临床疗效确切,有助于改善患儿的咳嗽症状,提高机体免疫功能。
Objective To investigate the clinical efficacy of Yupingfeng granule combined with montelukast sodium in the treatment of children with recurrent respiratory tract infection after cough. Methods 200 cases of children with cough after recurrent respiratory tract infection admitted to Liucheng Maternal and Child Health Care Hospital from 2013 to 2015 were randomly divided into A, B, C and D groups, 50 cases each. A group of children given antibiotics treatment, B group of children given montelukast sodium treatment on the basis of group A, C group of children treated with Yupingfeng particles on the basis of group A, D group children given Yupingfeng particles combined Montelukast sodium treatment, four groups of children were treated for 3 months. The clinical efficacy, CD_8 ~ + cell fraction, CD_4 ~ + cell fraction, CD_4 ~ + / CD_8 ~ + cell ratio, immunoglobulin G (IgG) and IgA in the four groups were compared before and after treatment. Results The clinical efficacy of group D was better than that of group A, B and C (P <0.05). There was no significant difference in clinical efficacy between group A, B and C (P> 0.05). Before treatment, there were no significant differences in the scores of CD_8 ~ +, CD_4 ~ +, CD_4 ~ + / CD_8 ~ + and IgG, IgA in the four groups (P> 0.05) The scores of CD_8 ~ + cells in children were lower than those in groups A, B and C, the percentage of CD_4 ~ + cells, the ratio of CD_4 ~ + / CD_8 ~ + cells and IgG, IgA in children were higher than those in groups A, B and C (P <0.05). Conclusion Yupingfeng granules combined with montelukast sodium in children with recurrent respiratory tract infection cough clinical curative effect is exact, will help to improve the children’s cough symptoms and improve the body’s immune function.