论文部分内容阅读
目的:探讨瑞舒伐他汀对冠心病患者血脂水平以及颈动脉粥样硬化斑块硬化程度的影响。方法:选择2013年2月至2014年12月我院收治的132例冠心病患者作为研究对象,将其随机分为研究组(66例)和对照组(66例),研究组应用瑞舒伐他汀(rosuvastatin calcium,RC)治疗,对照组采用常规药物治疗,观察和比较两组患者的血脂水平变化情况及颈动脉粥样硬化斑块硬化(IMT)程度的改善情况。结果:两组的总胆固醇(total c holesterol,T C)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)、甘油三酯(triglyceride,T G)水平较治疗前均有降低,高密度脂蛋白胆固醇(High density lipoprotein cholesterol,HDL-C)水平较治疗前有升高,研究组变化更显著,组间差异有统计学意义(P<0.05)。两组颈动脉粥样硬化斑块硬化程度较治疗前有改善,研究组优于对照组,差异有统计学意义(P<0.05)。研究组与对照组治疗总有效率分别为98.5%、71.2%,差异有统计学意义(P<0.05)。结论:瑞舒伐他汀能够有效降低冠心病患者的血脂水平,并能改善其颈动脉粥样硬化的程度。
Objective: To investigate the effect of rosuvastatin on the blood lipid level and the degree of carotid atherosclerosis in patients with coronary heart disease. Methods: A total of 132 patients with coronary heart disease admitted to our hospital from February 2013 to December 2014 were randomly divided into study group (66 cases) and control group (66 cases). The study group was given rosuvastatin Rosuvastatin calcium (RC). The control group was treated with conventional drugs. The changes of blood lipid level and the degree of carotid atherosclerosis (IMT) were observed and compared between the two groups. Results: The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) in both groups were lower than those before treatment. The levels of high density lipids High density lipoprotein cholesterol (HDL-C) levels were higher than before treatment, the study group changes more significantly, the difference between the two groups was statistically significant (P <0.05). The degree of atherosclerotic plaque in the two groups was improved compared with that before treatment, the study group was better than the control group, the difference was statistically significant (P <0.05). The total effective rates of the study group and the control group were 98.5% and 71.2%, respectively, with significant differences (P <0.05). Conclusion: Rosuvastatin can effectively reduce the level of lipid in patients with coronary heart disease and improve the degree of carotid atherosclerosis.