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目的 探讨自制万古霉素质控血清在血药浓度监测中应用的可行性.方法 取注射用盐酸万古霉素1.0 mg,注射用水溶解后加入血清基质液,制备质量浓度分别为10,20,30 μg·mL-1的万古霉素质控血清并检测其浓度,考察方法准确性、质控样品的稳定性及临床应用. 结果 自制低、中、高浓度的万古霉素质控血清检测结果为靶值的98.0%~101.5%,-30 ℃保存6个月含量变化小于2%. 结论 自制万古霉素质控血清操作方法简单、成本低、结果准确可靠,可以作为实验室日常质量控制.“,”Objective To evaluate self -made vancomycin quality -control serum used in blood drug concentration monitoring .Methods To prepare 10,20,30 μg·mL-1 vancomycin quality -control serum. The preparation, repeatability, sample stability and clinical application were studied.Results The results of low, medium and high concentra-tion of vancomycin quality-control serum was 98.0%-101.5%.The content change of vancomycin was less than 2% while saved at -30 ℃within 6 months.Conclusion The method for preparation of self-made vancomycin quality-control serum is simple, cost-effective, accurate and reliable, which can be used as daily laboratory quality control saved at -30℃.