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目的 了解脑胶质瘤中P53、PKC、VEGF阳性表达与脑胶质瘤分级和预后的关系。方法 采用兔疫组化SABC法观察P53、PKC、VEGF在脑胶质瘤中的表达;同时,随访了解患者生存情况。结果 P53、PKC、VEGF在BG、MG、HMC三组中都有不同程度的表达,而且,随着病理分级的增加,其表达率也逐渐增加,但各组间缺乏统计学差异,三者表达在脑胶质瘤中的意义有待进一步大宗病例的分析。P53、PKC、VEGF阴性表达与阳性表达在生存期上存在显著性差异(P<0.05),即表达阴性比表达阳性者预后好。结论 P53、PKC、VEGF的阳性表达与脑胶质瘤预后有着密切关系,此结果对于指导临床治疗有一定的价值。
Objective To investigate the relationship between the positive expression of P53, PKC and VEGF in gliomas and the grading and prognosis of gliomas. Methods The expression of P53, PKC and VEGF in gliomas were observed by immunohistochemical staining with SABC method. At the same time, the patients were followed up for survival. Results The expressions of P53, PKC and VEGF were all significantly different in BG, MG and HMC groups, and the expression rates of P53, PKC and HMC were also increased with the increase of pathological grade, but there was no statistical difference between the three groups The significance of glioma needs further analysis of large cases. P53, PKC, VEGF negative expression and positive expression in the survival of significant differences (P <0.05), that is negative expression than the positive prognosis. Conclusion The positive expressions of P53, PKC and VEGF are closely related to the prognosis of gliomas. The results are valuable in guiding the clinical treatment.