Controlled Release of the Indomethacin Microencapsulation Based on Layer-by-layer Assembly by Polyel

• 作 者: CHEN You-fang LIN Xian-fu
• 机 构: Department of Chemistry, Zhejiang University, Hangzhou 310027, China
• 出 处: 中国生物医学工程学报（英文版）
• 发表日期: 2007年1期
• 关键词: Indomethacin Encapsulated Controlled release Self-assembly Polyelectrolyte

Indomethacin has been encapsulated with polyelectrolyte multilayers for controlled release. Gelatin and alginate were altatively deposited on indomethacin microcrystals. The released amount of indomethacin from coated microcrystals in pH6. 8phosphate buffer solution (PBS) was measured with a UV spectrophometer. The polyelectrolyte multilayer capsule thickness was proved to control the release rate. The effects of osmotic pressure existed during the release process of indomethacin from microcapsules coated by (gelatin/alginate) 4.