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[目地]探讨乳腺微腺性腺病(MGA)的临床特点、病理诊断及转归。[方法]分析MGA患者的临床病理材料,并复习相关文献。[结果]组织学上乳腺组织内见腺管弥漫性增生,排列紊乱,分布于间质及脂肪组织中,增生的腺管被覆单层立方或扁平上皮,缺乏肌上皮细胞。部分区域腺管上皮明显异型,并见核分裂,其周围缺乏基底膜,间质见多灶性黏液软骨样基质形成,诊断为乳腺微腺性腺病伴产基质的癌。免疫组化表达:上皮和间质S-100(+),上皮EMA(+)、CK7(+)、AE1/AE3(+),而ER、PR、CerbB-2、SMA、MSA、Calponin、P63均阴性,Laminin、Ⅳ型胶原、网状纤维染色部分区域阴性。[结论]乳腺微腺性腺病是一种少见的病变,本身可能就是一种癌前病变且与乳腺癌关系密切。
[Objective] To investigate the clinical features, pathological diagnosis and prognosis of breast micro-adenosis (MGA). [Methods] To analyze the clinicopathological materials of MGA patients and to review the relevant literature. [Results] Histologically, duodenal glands were diffusely proliferated and disorganized in the interstitial and adipose tissue. The hyperplastic glands were covered with monolayers of cubic or flat epithelium and lacked myoepithelial cells. Part of the regional ductal epithelium was abnormal, and see the nuclear fission, the lack of basement membrane around, interstitial multifocal mucoid cartilage-like matrix formation, diagnosis of breast micro-adenosis with matrix-producing cancer. Immunohistochemical expression of epithelial and interstitial S-100 (+), epithelial EMA (+), CK7 (+) and AE1 / AE3 (+), while ER, PR, CerbB- 2, SMA, MSA, Calponin, All were negative, Laminin, type Ⅳ collagen, reticular fiber staining of some areas negative. [Conclusion] Breast adenosis is a rare lesion, itself may be a precancerous lesion and closely related to breast cancer.