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众所周知,O_3和/或NO_2等污染空气可以引起或加重微生物的呼吸道感染。在一些研究中已发现这些气体能损害呼吸道粘膜的纤毛清除作用和肺内杀菌活性等抗感染的防御机能。但是病毒的生长过程比细菌更为复杂,呼吸道抗病毒感染能力的降低而引起发病的机理还不象其对细菌那样能得到很好的阐明。已知肺泡巨噬细胞对呼吸道病毒感染起生物防御作用。有些实验研究阐明这些气体可使家兔肺泡巨噬细胞的吞噬功能受抑制,但还未能证明吸入O_3或光化学氧化剂(OX)能影响肺
It is well-known that polluted air such as O 3 and / or NO 2 can cause or aggravate the respiratory tract infection of microorganisms. In some studies, it has been found that these gases can impair the defensive function of respiratory tract mucosa such as ciliary clearance and antimicrobial activity in the lungs. However, the virus’s growth process is more complicated than that of bacteria, and the mechanism of pathogenesis caused by the reduction of respiratory virus antiviral infection is not as well elucidated as that of bacteria. Alveolar macrophages are known to have a biological defensive effect on respiratory viral infections. Some experimental studies have shown that these gases can inhibit the phagocytosis of rabbit alveolar macrophages, but have not been able to demonstrate that inhalation of O 3 or photochemical oxidants (OX) can affect lung