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在抗Ｔｈｙ１．１抗体引起的大鼠系膜增殖性肾炎中，肾小球的增殖性细胞核抗原（ｐｒｏｌｉｆｅｒ－ａｔｉｎｇｃｅｌｌｎｕｃｌｅａｒａｎｔｉｇｅｎ，ＰＣＮＡ）阳性细胞增多，￣３Ｈ－胸腺嘧啶核苷（￣３Ｈ－ｔｈｙｍｉｄｉｎｅ，￣３Ｈ－ＴｄＲ）掺入法测定的肾小球增殖活性（ｇｌｏｍｅｒｕｌａｒｐｒｏｌｉｆｅｒａｔｉｖｅａｃｔｉｖｉｔｙ，ＧＰＡ）升高。对肾炎鼠给予５－脂氧合酶抑制剂ＭＫ８８６或血栓素（ｔｈｒｏｍｂｏｘａｎｅＡ２，ＴＸＡ２）合成酶抑制剂Ｆｕｒｅｇｒｅｌａｔｅ或１２－脂氧合酶抑制剂Ｂａｉｃａｌｅｉｎ进行处理，可分别抑制肾小球合成的白三烯（ｌｅｕｋｏｔｒｉｃｎｅ，ＬＴ）Ｂ４ 及１２－羟二十碳四烯酸（１２－ｈｙｄｒｏｘｙｅｉｃｏｓａｔｅｔｒａｅｎｏｉｃａｃｉｄ，１２－ＨＥＴＥ），同时也抑制ＰＣＮＡ（＋）细胞及ＧＰＡ的上升。用Ｘ线照射或抗血小板抗体分别去除肾炎鼠的循环白细胞或血小板，均可抑制ＰＣＮＡ（＋）细胞及ＧＰＡ的上升。结果提示白细胞及血小板衍生的ＬＴ、ＴＸＡ＿２及１２－ＨＥＴＥ参与本模型的系膜细胞增殖。
Thy1.1 antibody-induced rat mesangial proliferative glomerulonephritis, glomerular proliferative cell nuclear antigen (prolifer-atingcellnuclearantigen, PCNA) positive cells, ~ 3H-thymidine (~ 3H-thymidine, ~ 3H-TdR incorporation assay showed increased glomerularproliferative activity (GPA). Nephritis mice were treated with 5-lipoxygenase inhibitor MK886 or thromboxane A2 (TXA2) synthase inhibitor Furegrelate or 12-lipoxygenase inhibitor Baicalein for the treatment of glomerular synthesis of leukotrienes Leukotricne (LT) B4 and 12-hydroxyeicosatetraenoic acid (12-HETE) as well as the increase of PCNA (+) cells and GPA. Using X-ray irradiation or anti-platelet antibody to remove circulating white blood cells or platelets of nephritic rats, respectively, can inhibit the increase of PCNA (+) cells and GPA. The results suggest that leukocytes and platelet-derived LT, TXA 2 and 12-HETE are involved in mesangial cell proliferation in this model.