论文部分内容阅读
本文试图解释壁细胞泌酸过程,并讨论以此为根据设计抑制酸分泌药物的可能性.消化道上皮与腔内各种环境接触,对其涉及的上皮结构复杂性知之甚微.目前溃疡的治疗仅限于控制腔内酸度,本文集中讨论如何减少胃酸分泌.壁细胞的功能可以被其基底及侧面膜上的三种受体所激活,即乙酰胆碱、胃泌素及组织胺的受体.此外,某些激素如表皮生长因子、生长抑素、前列腺素可能通过内分泌或旁分泌途径抑制壁细胞.毒蕈碱受体通过钙离子依赖方式激活壁细胞.基
This article attempts to explain the process of acid secretion in the parietal cells and discusses the possibility of using this as a basis for the inhibition of acid-secreting drugs.The contact of the digestive epithelium with the various compartments in the lumen is poorly understood with regard to the complexity of epithelial structures involved Treatment is limited to the control of intracavity acidity, this article focuses on how to reduce gastric acid secretion.Globocyte function can be activated by the three receptors on its basal and lateral membranes, namely acetylcholine, gastrin and histamine receptors.In addition , Some hormones such as epidermal growth factor, somatostatin, prostaglandins may inhibit parietal cells through the endocrine or paracrine pathway Mus muscarinic receptors activate parietal cells in a calcium-dependent manner