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周围神经损伤是临床中常见的神经损伤之一,神经胶质细胞和信号通路转导在周围神经损伤和再生修复中发挥重要作用。小胶质细胞的活化与周围神经损伤导致的神经损伤及疼痛密切相关,小胶质细胞是周围神经损伤与修复的关键场所。脊髓背角的小胶质细胞可被嘌呤信号通路的P2Y_(12)受体活化,进而导致p38MAPK磷酸化,造成相关神经损伤及感觉功能障碍。以脊髓背角的小胶质细胞为靶点,从P2Y_(12)受体-p38MAPK通路的角度可揭示周围神经损伤的部分可能机制。探究从嘌呤信号通路与小胶质细胞活化的新角度,将神经损伤后的P2Y_(12)受体与p38MAPK的磷酸化表达联系为P2Y_(12)受体-p38MAPK通路,可为临床治疗周围神经损伤提供新的思路。本文就周围神经损伤中P2Y_(12)受体-p38MAPK通路的研究进展作一综述。
Peripheral nerve injury is one of the most common nerve injuries in clinical practice. Glia and signal transduction play an important role in peripheral nerve injury and regenerative repair. The activation of microglia is closely related to nerve injury and pain caused by peripheral nerve injury. Microglia are the key sites of peripheral nerve injury and repair. Microglia in the dorsal horn of the spinal cord can be activated by the P2Y_ (12) receptor of the purine signaling pathway, leading to phosphorylation of p38MAPK, resulting in the related nerve damage and sensory dysfunction. Taking the microglia of spinal dorsal horn as a target, some possible mechanism of peripheral nerve injury can be revealed from the perspective of P2Y_ (12) receptor-p38MAPK pathway. To explore the relationship between P2Y_ (12) receptor and phosphorylation of p38MAPK, a P2Y_ (12) receptor-p38MAPK pathway, from a new perspective of purine signaling pathway and microglial activation, Damage provides a new way of thinking. This article reviews the progress of the P2Y_ (12) receptor-p38MAPK pathway in peripheral nerve injury.