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Purpose: To correlate retinal circulatory measurements using scanning laser fl uorescein angiography and flow velocities of retrobulbar vessels measured by mea ns of colour Doppler imaging. Methods: Fifteen patients with normal pressure gla ucoma (NPG) and 15 healthy volunteers underwent colour Doppler imaging and fluor escein angiographic studies. Peak systolic velocities (PSVs), end-diastolic velocities (EDVs) and resistive indices (RIs) of the ophthalmic artery (OA) an d central retinal artery were obtained. In the fluorescein angiograms arterioven ous passage time (AVP) was quantified by means of digital dye dilution curve ana lysis. Results: Arteriovenous passage time was significantly prolonged in NPG pa tients compared to healthy subjects (P=0.0026). In the central retinal artery PS V (P=0.023) and EDV (P < 0.0001) were significantly decreased and RI was increas ed (P < 0.0001) in patients with NPG. The EDV of the central retinal artery show ed a significant correlation with AVP (EDV: r=-0.53, P=0.0023). The RI of the c entral retinal artery correlated significantly to AVP (RI: r= 0.63, P< 0.0001). The AVP did not correlate to EDV or PSV, nor to the RI measured in the ophthalmi c artery. Conclusion: Arteriovenous passage time, which represents blood flow in a vascular segment of artery, capillary bed and corresponding vein, was found t o be correlated to the EDV and the RI of the central retinal artery. The combina tion of different techniques allows further interpretation of ocular circulatory responses.
Methods: Fifteen patients with normal laser glaucoma (NPG) and 15 healthy volunteers underwent color Doppler imaging and fluor In the fluorescein angiography arteriovenous passage time (AVP), the peak systolic velocities (PSVs), end-diastolic velocities (EDVs) and resistive indices (RIs) of the ophthalmic artery Results: Arteriovenous passage time was significantly prolonged in NPG pa tients compared to healthy subjects (P = 0.0026). In the central retinal artery PS V (P = 0.023) and EDV (P <0.0001) were significantly decreased and RI was increas ed (P <0.0001) in patients with NPG. The EDV of the central retinal artery show ed a significant correlation with AVP (EDV: r = -0.53, P = 0.0023) The RI of the c entral retinal artery clinically significantly to AVP (RI: r = 0.63, P <0.0001). The AVP did not correlate to EDV or PSV, nor to the RI measured in the ophthalmi c artery. Conclusion: Arteriovenous passage time, which represents blood flow in a vascular segment of artery, capillary bed and corresponding vein, was found to be correlated to the EDV and the RI of the central retinal artery. The combina tion of different techniques allows further interpretation of ocular circulatory response.