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肿瘤具有刺激新生血管生长的能力似为肿瘤分泌的可扩散物质所引起,该物质为肿瘤发生血管因素(Tumor angiogenesis factor,TAF)。为研究糖尿病视网膜病变中毛细血管增生可能与相似化学物质有关,作者以前曾将兔癌植入兔玻璃体内,观察肿瘤对视网膜血管的影响。发现仅当肿瘤与视网膜直接接触时才引起视网膜新生血管形成。但当同一肿瘤植入角膜内或前房内。距植入肿瘤2～5毫米,角巩膜缘或虹膜内均引起新生血管。这一差别的一种解释是玻璃体内可能存在一种能抑制毛细血管增生的物质。本文报告试验结果支持这个假说。自60只眼抽取5个月的白兔的玻璃体各1毫升。以免角膜植入肿瘤块后,每天一次注射玻璃体于角膜内未见有抑制新生血管的作用。这可能是假定的抑制物质于注射后在角膜内迅速扩散之故。作者又以肿瘤小块植入角膜,同时以具有缓慢释放物质的高分子聚合物小块放入角膜内做实验研究:以含有玻璃体提取物之高分子聚合物与不含提取物者做对比观察。未植入肿瘤块者均无新生血管发生,亦无炎症反应。植入肿瘤块者则均有新生血管生长,但含有玻璃体提取物者新生
Tumor has the ability to stimulate neovascularization caused by tumor-secreting diffusible material, which is tumor angiogenesis factor (TAF). In order to study the pathogenesis of diabetic retinopathy, capillary hyperplasia may be related to similar chemical substances. The authors previously implanted rabbit glass into rabbit vitreous and observed the effect of tumor on retinal blood vessels. It was found that retinal neovascularization was caused only when the tumor was in direct contact with the retina. But when the same tumor is implanted in the cornea or in the anterior chamber. 2 to 5 mm from the tumor implanted, corneal limbus or iris are caused by neovascularization. One explanation for this difference is that there may be a substance in the vitreous that inhibits capillary proliferation. This article reports the test results in support of this hypothesis. 1 ml of vitreous body of white rabbits of 5 months from 60 eyes. In order to avoid corneal tumor mass, once a day injection of vitreous in the cornea no inhibit angiogenesis. This may be the presumed suppression of rapid diffusion of substance within the cornea after injection. The authors again tumor small pieces of corneal implants, at the same time with a slow release material into the cornea of small pieces of polymer experiments: the vitreous extract containing polymer and non-extractable were compared . Neither implanted neoplasm nor neovascularization, nor inflammatory reaction. Implanted tumor mass who have neovascularization, but those who contain vitreous extract newborn