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乙型肝炎病毒(HBV)所致的慢性肝病和肝癌之间有密切关系。HBV无症状携带者中肝癌发生率显著地高于自然人群,肝癌患者家族中具有明显的HBsAg阳性、慢性肝病和肝癌的积聚现象。上海医科大学中山医院免疫室对15例肝癌患者家庭成员进行了系统的血清学HBV感染标志和HBVDNA检测。 他们在直系或近亲血缘中具有肝癌病史的115例(93个家庭)本地居民中进行详细的家属肝癌病史、木人肝病史调查,并抽取静脉血进行血清HBV感染五项标志的测定。 结果表明,肝癌患者家庭成员的HBV感染是严重的。115例中有明确肝炎病史者占81.7％,其中48例具有10～20年以上的病史。而21例无肝炎病史者HBsAg、Anti-HBc和HBeAg阳性率亦分别高达61.9％、59.2％和28.6％。全组HBsAg阳性率与自然人群相比,呈显著性差异;Anti-HBs阳性率比肝癌组明显为高,同时发现母系肝癌
There is a close relationship between chronic liver disease caused by hepatitis B virus (HBV) and liver cancer. The incidence of hepatocellular carcinoma in asymptomatic carriers of HBV is significantly higher than that of the natural population, and the accumulation of HBsAg-positive, chronic liver disease and hepatocellular carcinoma in the family of hepatocellular carcinoma patients is obvious. Systematic serological markers of HBV infection and HBVDNA were detected in 15 cases of HCC patients in immunization room of Zhongshan Hospital of Shanghai Medical University. They conducted a detailed family history of hepatocellular carcinoma and a history of wooden human liver disease in 115 (93 families) local residents with a history of hepatocellular carcinoma in their immediate or near relatives and measured venous blood for five markers of serum HBV infection. The results show that HBV infection in family members of patients with liver cancer is serious. Of the 115 patients who had a definite history of hepatitis, 81.7% had history of hepatitis and 48 of them had a history of 10-20 years. The positive rates of HBsAg, Anti-HBc and HBeAg were 21.9%, 59.2% and 28.6% respectively in 21 cases without history of hepatitis. The positive rate of HBsAg in the whole group was significantly different from that in the natural population. The positive rate of Anti-HBs was significantly higher than that in the HCC group,