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目的：测定急性脑梗塞患者血清髓鞘碱性蛋白(MBP)含量变化,探讨其临床意义。方法:采用酶联免疫吸附检测法测定了42例急性脑梗塞患者血清MBP含量,并对其中38例患者进行了动态观察。结果:疾病组急性期较对照组显著增高(P<0.001),恢复期较急性期显著降低(P<0.001)。结论:脑梗塞患者急性期血清MBP含量显著增高,恢复期含量降低,其含量的高低一定程度上反映了脑实质损害的范围及严重程度,从生化方面深入了解脑实质损害与修复。
Objective: To determine the change of serum MBP in patients with acute cerebral infarction and to explore its clinical significance. Methods: Serum MBP levels were measured in 42 patients with acute cerebral infarction by enzyme-linked immunosorbent assay, and 38 of them were observed dynamically. Results: The acute phase in the disease group was significantly higher than that in the control group (P <0.001), and the recovery period was significantly lower than that in the acute phase (P <0.001). Conclusion: The levels of serum MBP in acute stage of cerebral infarction are significantly increased and the content of convalescent stage is decreased in some extent. The content and severity of cerebral parenchyma in some extent reflect the extent and severity of brain parenchymal damage.